The US FDA has not approved any medications for the treatment of methamphetamine (METH) use disorders. Currently, cognitive-behavioral and contingency-management interventions are the most effective treatments. IXT-m200, a monoclonal antibody that specifically binds METH in the blood, is being developed as a pharmacological treatment for use in conjunction with behavior therapies. Based on nonclinical studies, IXT-m200 is expected to alter METH pharmacokinetics in human subjects resulting in reduced or blocked METH subjective effects that reinforce METH use.
Two decades ago, President George W. Bush established the White House Faith-Based and Community Initiative to encourage and coordinate community activities in providing social services. This initiative was renewed by Presidents Obama and Biden. But these renewals exclude a focus of faith-based and community groups on problems like substance abuse and addiction. Does the rise of medication-assisted treatment play a role in this exclusion?
Methadone and various formulations containing buprenorphine are treatment drugs used in medication-assisted treatment, usually referred to as MAT. These are the MAT drugs approved for treatment of opioid addiction (opioid painkillers, heroin, fentanyl). We will take a look at the minus side as well as the plus side of these opioid addition treatment drugs. Treatment with MAT drugs can be right for some people. But anyone choosing this treatment so they can leave addiction behind should be prepared for the minus side of MAT.
In 2018, McKesson committed the astronomical sum of $100 million to support a new non-profit group, the FORE Foundation. Is there any reason, really, to think twice about this collaboration between McKesson and the FORE Foundation? The answer might be "yes." This type of action was one of the tactics used by Purdue Pharma to smooth the path to increased opioid prescribing—getting a non-profit to spend your money making increased use of your products possible. In the end, even this move could be all about profits.
The powerful hallucinogen LSD (lysergic acid diethylamide) has potential as a treatment for alcoholism, according to a retrospective analysis of studies published in the late 1960s and early 1970s… Psychedelics were promoted by psychiatrists in the 1950s as having a range of medical uses — to treat conditions such as schizophrenia, for example — before political pressures in the United States and elsewhere largely ended the work.
A stunning report this week that an estimated 93,000 people died of drug overdoses in 2020 has renewed attention on the nation’s other epidemic: The drug crisis that the government, health-care workers and street-level activists have been battling unsuccessfully for more than two decades... A wide spectrum of changes has been offered by government, academic and think tank researchers, criminal justice experts and health-care workers, and lay people to try to help the nation’s more than 8.1 million people with substance use disorders. Solutions range from completely decriminalizing the consumption of drugs, as Portugal did in 2001, to overturning the way the health-care system treats users.
The prevalence of serotonin syndrome, which, at its most severe, is a potentially life-threatening drug reaction that increases serotonin levels, is strikingly high in patients receiving buprenorphine (Suboxone, Reckitt Benckiser) on an outpatient basis for opioid addiction, a single-center study shows. "The Suboxone clinic presented so many cases, so many women having ankle clonus and agitation and tremor, I thought that this was worth reporting. In fact, 43% of our patients showed some degree of serotonin syndrome. Yet, many mild and moderate cases of serotonin syndrome go unrecognized," lead researcher Shawn Cassady, MD, from the First Step clinic, in Cockeysville, Maryland, told Medscape Medical News.
Navigating the many choices of recovery programs can be baffling until you grasp the Four Dimensions of Recovery outlined by the Substance Abuse and Mental Health Services Administration. These dimensions provide insight into the qualities of a rehabilitation program that has a chance of true and lasting success.
An uprising is taking place in San Francisco. In a city now known as much for its humanitarian crisis and social breakdown as for its steep hills and beautiful bridges, formerly incarcerated people, mostly black men, are refusing to be homeless, addicted, and unprepared for life and success. On September 7, the Positive Directions Treatment, Recovery, and Prevention Academy, an alternative-sentencing program that serves up to 84 formerly incarcerated men, opened its doors. Program participants receive up to 30 months of transformational support in a structured residential setting, at no cost to them. Spearheaded by Steve Adami, director of the Adult Probation Department’s Reentry Division, and in partnership with Westside Community Services and Positive Direction Equals Change, the Academy works to help former prisoners live honorably and independently.
NEW YORK, Dec 16 (Reuters) - A federal judge overturned a roughly $4.5 billion settlement that legally shielded members of the Sackler family who stand accused of helping fuel the U.S. opioid epidemic, a decision that threatened to upend the bankruptcy reorganization of their company, OxyContin maker Purdue Pharma LP.
U.S. District Judge Colleen McMahon said in a written opinion on Thursday the New York bankruptcy court that approved the settlement did not have authority to grant the Sacklers the legal protection from future opioid litigation that formed the linchpin of Purdue’s reorganization.